Published Research

The Insulin Plant (Costus Igneus) Published Research

Costus igneus, commonly known as insulin plant is believed to lower blood glucose levels and diabetics who consumed the leaves of this plant did report a fall in their blood glucose levels.

There have been a collection of studies published explaining the positive correlations between the leaves of costus igneus and individuals with diabetes. The leaves are rich in protein, iron and a number of antioxidant components such as B-carotene and a-tocopherol. These properties, in combination with its “natural insulin” content (phyto-compounds that simulate the metabolic action of insulin when ingested), aids in C. igneus’ ability to lower blood sugar in individuals with diabetes. 

Below are research articles on costus igneus the insulin plant:

Effect of the insulin plant (Costus Igneus) leaves on blood glucose levels in diabetic patients : A cross sectional study.

Shetty, A. J.; Parampalli, S. M.; Bhandarkar, R.; Kotian, S.Journal of Clinical and Diagnostic Research, Vol. 4, No. 3, 17.12.2010, p. 2617-2621.

A review on Insulin plant (Costus igneus Nak).

Hegde PK, Rao HA, Rao PN.
Pharmacogn Rev. 2014 Jan;8(15):67-72. doi: 10.4103/0973-7847.125536.
PMID: 24600198

Effect of Costus igneus stem extract on calcium oxalate urolithiasis in albino rats.

Manjula K, Rajendran K, Eevera T, Kumaran S.
Urol Res. 2012 Oct;40(5):499-510. doi: 10.1007/s00240-012-0462-6.
PMID: 22298189

Elucidation of hypoglycemic action and toxicity studies of insulin-like protein from Costus igneus.

Hardikar MR, Varma ME, Kulkarni AA, Kulkarni PP, Joshi BN.
Phytochemistry. 2016 Apr;124:99-107. doi: 10.1016/j.phytochem.2016.02.001. Epub 2016 Feb 4.
PMID: 26854130

Effect of the insulin plant (Costus igneus) leaves on dexamethasone-induced hyperglycemia.

Shetty AJ, Choudhury D, Rejeesh, Nair V, Kuruvilla M, Kotian S.
Int J Ayurveda Res. 2010 Apr;1(2):100-2. doi: 10.4103/0974-7788.64396.
PMID: 20814523

Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus.

Krishnan K, Mathew LE, Vijayalakshmi NR, Helen A.
Inflammopharmacology. 2014 Dec;22(6):373-85. doi: 10.1007/s10787-014-0218-8. Epub 2014 Oct 10.
PMID: 25300965

In vitro evaluation of calcium oxalate monohydrate crystals influenced by Costus igneus aqueous extract.

Kesavan M, Kaliaperumal R, Tamilmani E, Shanmugam K.
Scand J Urol Nephrol. 2012 Aug;46(4):290-7. doi: 10.3109/00365599.2012.669792. Epub 2012 May 1.
PMID: 22545945

Orally active hypoglycemic protein from Costus igneus N. E. Br.: an in vitro and in vivo study.

Joshi BN, Munot H, Hardikar M, Kulkarni AA.
Biochem Biophys Res Commun. 2013 Jun 28;436(2):278-82. doi: 10.1016/j.bbrc.2013.05.093. Epub 2013 Jun 4.
PMID: 23743192

Synthesis of ZnO nanoparticles using insulin-rich leaf extract: Anti-diabetic, antibiofilm and anti-oxidant properties.

Vinotha V, Iswarya A, Thaya R, Govindarajan M, Alharbi NS, Kadaikunnan S, Khaled JM, Al-Anbr MN, Vaseeharan B.
J Photochem Photobiol B. 2019 Aug;197:111541. doi: 10.1016/j.jphotobiol.2019.111541. Epub 2019 Jun 25.
PMID: 31272033

Hypoglycemic potential of Morus indica. L and Costus igneus. Nak.--a preliminary study.

Devi VD, Urooj A.
Indian J Exp Biol. 2008 Aug;46(8):614-6.
PMID: 18814491

Isolation, Identification, Whole-Genome Sequencing, and Annotation of Four Bacillus Species, B. anthracis RIT375, B. circulans RIT379, B. altitudinis RIT380, and B. megaterium RIT381, from Internal Stem Tissue of the Insulin Plant Costus igneus.

Polter SJ, Caraballo AA, Lee YP, Eng WW, Gan HM, Wheatley MS, Savka MA, Thomas BN, Hudson AO.
Genome Announc. 2015 Jul 30;3(4):e00847-15. doi: 10.1128/genomeA.00847-15.
PMID: 26227604

Screening for Diosgenin in Rhizomes from 3 Costus Species (C. deistellii, C. igneus, C. lucanusianus).

Lambert N, Baccou JC, Sauvaire Y.
Planta Med. 1988 Aug;54(4):366-7. doi: 10.1055/s-2006-962465.
PMID: 17265293

Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats.

Kalailingam P, Kannaian B, Tamilmani E, Kaliaperumal R.
Phytomedicine. 2014 Sep 15;21(10):1154-61. doi: 10.1016/j.phymed.2014.04.005. Epub 2014 Jun 2.
PMID: 24889525