Published Research

The Insulin Plant (Costus Igneus) Published Research

Costus igneus, commonly known as insulin plant is believed to lower blood glucose levels and diabetics who consumed the leaves of this plant did report a fall in their blood glucose levels.

There have been a collection of studies published explaining the positive correlations between the leaves of costus igneus and individuals with diabetes. The leaves are rich in protein, iron and a number of antioxidant components such as B-carotene and a-tocopherol. These properties, in combination with its “natural insulin” content (phyto-compounds that simulate the metabolic action of insulin when ingested), aids in C. igneus’ ability to lower blood sugar in individuals with diabetes. 

Below are research articles on costus igneus the insulin plant:

Effect of the insulin plant (Costus Igneus) leaves on blood glucose levels in diabetic patients : A cross sectional study.

Shetty, A. J.; Parampalli, S. M.; Bhandarkar, R.; Kotian, S.Journal of Clinical and Diagnostic Research, Vol. 4, No. 3, 17.12.2010, p. 2617-2621.

A review on Insulin plant (Costus igneus Nak).

Hegde PK, Rao HA, Rao PN.
Pharmacogn Rev. 2014 Jan;8(15):67-72. doi: 10.4103/0973-7847.125536.
PMID: 24600198

Effect of Costus igneus stem extract on calcium oxalate urolithiasis in albino rats.

Manjula K, Rajendran K, Eevera T, Kumaran S.
Urol Res. 2012 Oct;40(5):499-510. doi: 10.1007/s00240-012-0462-6.
PMID: 22298189

Elucidation of hypoglycemic action and toxicity studies of insulin-like protein from Costus igneus.

Hardikar MR, Varma ME, Kulkarni AA, Kulkarni PP, Joshi BN.
Phytochemistry. 2016 Apr;124:99-107. doi: 10.1016/j.phytochem.2016.02.001. Epub 2016 Feb 4.
PMID: 26854130

Effect of the insulin plant (Costus igneus) leaves on dexamethasone-induced hyperglycemia.

Shetty AJ, Choudhury D, Rejeesh, Nair V, Kuruvilla M, Kotian S.
Int J Ayurveda Res. 2010 Apr;1(2):100-2. doi: 10.4103/0974-7788.64396.
PMID: 20814523

Anti-inflammatory potential of β-amyrin, a triterpenoid isolated from Costus igneus.

Krishnan K, Mathew LE, Vijayalakshmi NR, Helen A.
Inflammopharmacology. 2014 Dec;22(6):373-85. doi: 10.1007/s10787-014-0218-8. Epub 2014 Oct 10.
PMID: 25300965

In vitro evaluation of calcium oxalate monohydrate crystals influenced by Costus igneus aqueous extract.

Kesavan M, Kaliaperumal R, Tamilmani E, Shanmugam K.
Scand J Urol Nephrol. 2012 Aug;46(4):290-7. doi: 10.3109/00365599.2012.669792. Epub 2012 May 1.
PMID: 22545945

Orally active hypoglycemic protein from Costus igneus N. E. Br.: an in vitro and in vivo study.

Joshi BN, Munot H, Hardikar M, Kulkarni AA.
Biochem Biophys Res Commun. 2013 Jun 28;436(2):278-82. doi: 10.1016/j.bbrc.2013.05.093. Epub 2013 Jun 4.
PMID: 23743192

Synthesis of ZnO nanoparticles using insulin-rich leaf extract: Anti-diabetic, antibiofilm and anti-oxidant properties.

Vinotha V, Iswarya A, Thaya R, Govindarajan M, Alharbi NS, Kadaikunnan S, Khaled JM, Al-Anbr MN, Vaseeharan B.
J Photochem Photobiol B. 2019 Aug;197:111541. doi: 10.1016/j.jphotobiol.2019.111541. Epub 2019 Jun 25.
PMID: 31272033

Hypoglycemic potential of Morus indica. L and Costus igneus. Nak.--a preliminary study.

Devi VD, Urooj A.
Indian J Exp Biol. 2008 Aug;46(8):614-6.
PMID: 18814491

Isolation, Identification, Whole-Genome Sequencing, and Annotation of Four Bacillus Species, B. anthracis RIT375, B. circulans RIT379, B. altitudinis RIT380, and B. megaterium RIT381, from Internal Stem Tissue of the Insulin Plant Costus igneus.

Polter SJ, Caraballo AA, Lee YP, Eng WW, Gan HM, Wheatley MS, Savka MA, Thomas BN, Hudson AO.
Genome Announc. 2015 Jul 30;3(4):e00847-15. doi: 10.1128/genomeA.00847-15.
PMID: 26227604

Screening for Diosgenin in Rhizomes from 3 Costus Species (C. deistellii, C. igneus, C. lucanusianus).

Lambert N, Baccou JC, Sauvaire Y.
Planta Med. 1988 Aug;54(4):366-7. doi: 10.1055/s-2006-962465.
PMID: 17265293

Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats.

Kalailingam P, Kannaian B, Tamilmani E, Kaliaperumal R.
Phytomedicine. 2014 Sep 15;21(10):1154-61. doi: 10.1016/j.phymed.2014.04.005. Epub 2014 Jun 2.
PMID: 24889525


Mango Leaf Powder Published Research

There are many emerging benefits of mango leaves. Mango leaves help in managing diabetes and obesity. They have been used in healing practices like Ayurveda and traditional Chinese medicine for thousands of years. They are also rich in various other nutrients.

Below are research articles on mango leaf powder:

Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis

Pleguezuelos-Villa M, Diez-Sales O, Manca ML, Manconi M, Sauri AR, Escribano-Ferrer E, Nácher A. Int J Pharm. 2020 Jan 5;573:118844. doi: 10.1016/j.ijpharm.2019.118844. Epub 2019 Nov 18.
PMID: 31751638

A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)

Ediriweera MK, Tennekoon KH, Samarakoon SR. Evid Based Complement Alternat Med. 2017;2017:6949835. doi: 10.1155/2017/6949835. Epub 2017 Dec 31.
PMID: 29456572; PMCID: PMC5804368

Terpenoids as plant antioxidants

Grassmann J. Vitam Horm. 2005;72:505-35. doi: 10.1016/S0083-6729(05)72015-X.
PMID: 16492481

The effects of polyphenols and other bioactives on human health

Fraga CG , Croft KD , Kennedy DO , Tomás-Barberán FA . Food Funct. 2019 Feb 20;10(2):514-528. doi: 10.1039/c8fo01997e.
PMID: 30746536

Mangiferin: An effective therapeutic agent against several disorders (Review)

Du S, Liu H, Lei T, Xie X, Wang H, He X, Tong R, Wang Y. Mol Med Rep. 2018 Dec;18(6):4775-4786. doi: 10.3892/mmr.2018.9529. Epub 2018 Oct 2.
PMID: 30280187

Mangiferin - a bioactive xanthonoid, not only from mango and not just antioxidant

Matkowski A, Kuś P, Góralska E, Woźniak D. Mini Rev Med Chem. 2013 Mar;13(3):439-55.
PMID: 23190031

Mangiferin: A xanthonoid with multipotent anti-inflammatory potential

Saha S, Sadhukhan P, Sil PC. Biofactors. 2016 Sep 10;42(5):459-474. doi: 10.1002/biof.1292. Epub 2016 May 24.
PMID: 27219011

Benzophenones from Mango Leaves Exhibit α-Glucosidase and NO Inhibitory Activities

Pan J, Yi X, Wang Y, Chen G, He X. J Agric Food Chem. 2016 Oct 12;64(40):7475-7480. doi: 10.1021/acs.jafc.6b02404. Epub 2016 Sep 27.
PMID: 27643634

Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial

Na L, Zhang Q, Jiang S, Du S, Zhang W, Li Y, Sun C, Niu Y. Sci Rep. 2015 May 19;5:10344. doi: 10.1038/srep10344.
PMID: 25989216; PMCID: PMC4437311

Mangiferin: a promising anticancer bioactive

Khurana RK, Kaur R, Lohan S, Singh KK, Singh B. Pharm Pat Anal. 2016 May;5(3):169-81. doi: 10.4155/ppa-2016-0003. Epub 2016 Apr 18.
PMID: 27088726

Protective effect of mango (Mangifera indica L.) against UVB-induced skin aging in hairless mice

Song JH, Bae EY, Choi G, Hyun JW, Lee MY, Lee HW, Chae S. Photodermatol Photoimmunol Photomed. 2013 Apr;29(2):84-9. doi: 10.1111/phpp.12030.
PMID: 23458392

Mangiferin modulation of metabolism and metabolic syndrome 

Fomenko EV, Chi Y. Biofactors. 2016 Sep 10;42(5):492-503. doi: 10.1002/biof.1309. Epub 2016 Aug 18.
PMID: 27534809; PMCID: PMC5077701

Effects of Benzophenones from Mango Leaves on Lipid Metabolism

Zhang Y, Chen Q, Liu MY, Ruan JY, Yu HY, Li J, Wang T. Chem Pharm Bull (Tokyo). 2019;67(7):634-639. doi: 10.1248/cpb.c18-00905.
PMID: 31257318